Claude Integrations: Connect Anthropic's AI to Your Existing Stack

Claude integrates with every major business tool through its API. Whether you're connecting Claude to your CRM, email, Slack, database, or custom application, the patterns are consistent and well-documented. This guide covers the most common Claude integrations and how to build them.

MJK Supplies · May 14, 2026 · 10 min read

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Claude Integrations: Connect Anthropic's AI to Your Existing Stack

Integration Architecture

Claude integrates with other tools in two main patterns:

Direct API integration: Your application calls the Claude API directly from your backend code. Gives full control, lowest latency, most flexibility. Requires development work.

Automation platform integration: n8n, Make.com, or Zapier connects Claude to other apps via visual workflow builder. Faster setup; less development required.

For simple, point-to-point integrations, automation platforms are faster. For complex workflows with custom logic or existing applications, direct API integration is better.

CRM Integration

HubSpot + Claude:

Use n8n with HubSpot's native node and Claude HTTP node:

New contact → Claude enriches with company research and talking points → update HubSpot contact
Deal stage change → Claude generates stage-appropriate follow-up email draft → HubSpot email draft
New support ticket via HubSpot → Claude classifies and suggests response → update ticket

Salesforce + Claude:

Salesforce → Make.com → Claude → back to Salesforce. Use Salesforce's "Opportunity updated" trigger to fire Claude analysis when deal data changes.

Apollo + Claude:

Apollo.io lead data → n8n → Claude personalises outreach → Apollo sequence.

Email Integration

Gmail + Claude (n8n):

Gmail trigger: new email received
Claude: classify intent (support, sales inquiry, partner, other) and draft response
Branch: if sales inquiry → add to CRM; if support → create ticket; if other → draft reply
Gmail: create draft reply for human review

Outlook + Claude (Make.com): Microsoft 365 trigger → Claude analysis → update calendar, send response, or create task.

Outreach / Salesloft + Claude: Prospect email reply received → Claude analyses intent and sentiment → update sequence step → alert sales rep with suggested response.

Slack Integration

Claude bot in Slack:

Slack app: listen for @claude mentions
n8n webhook: receive mention event
Claude: process the request in context of conversation history
Slack API: post response in thread

This creates a team-accessible Claude assistant in your Slack workspace.

Slack alerts from Claude: Any workflow that produces a Claude output can push notifications to Slack:

n8n workflow → Claude analysis → "if urgent" → Slack message to channel
Daily digest from Claude → formatted Slack message to #morning-updates

Database Integration

PostgreSQL / MySQL / Supabase:

n8n has native database nodes. Pattern:

Query database for relevant records
Format as context for Claude
Claude processes and returns structured output
Update database with results

Example: Customer table → Claude scores lead quality → update lead_score column.

Airtable + Claude:

Airtable is particularly well-suited as a Claude workflow data layer:

Store content briefs in Airtable
n8n/Make.com triggers on new rows
Claude processes brief → generates content
Content returned to Airtable record

Communication Platform Integration

WhatsApp + Claude (Twilio):

Twilio WhatsApp webhook → n8n → Claude → Twilio reply. Creates a Claude-powered WhatsApp support bot or sales assistant.

SMS + Claude (Twilio):

Same pattern for SMS. Useful for appointment reminders with intelligent follow-up, or brief-format support.

Intercom + Claude:

Intercom webhook (new conversation) → n8n → Claude with knowledge base context → Intercom reply API. First-response support automation.

Document Storage Integration

Google Drive / OneDrive:

New document uploaded → fetch content → Claude summarises or classifies → update document properties or notify team.

Notion + Claude:

Notion database trigger → Claude generates page content from template + brief → create Notion page. Powerful for automated wiki or knowledge base content creation.

Dropbox + Claude:

New file trigger → Claude analyses content → metadata update or team notification.

Custom Application Integration

For custom apps, direct SDK integration is best:

// Node.js / TypeScript import Anthropic from '@anthropic-ai/sdk'; const client = new Anthropic({ apiKey: process.env.ANTHROPIC_API_KEY }); export async function analyseWithClaude(data: any, task: string): Promise<string> { const response = await client.messages.create({ model: 'claude-sonnet-4-6', max_tokens: 1024, system: 'You are a business analyst for [Company]. Be specific and action-oriented.', messages: [{ role: 'user', content: `${task}\n\nData: ${JSON.stringify(data)}` }] }); return response.content[0].text; }